DREaM: Component-Specific Air pollutant Drivers of Disease Risk in Early to Midlife: a pathway approach

Led by: Dr Ian Mudway, Imperial College London

Project partners: Imperial College London, Durham University, University of Cambridge

High pollutant concentrations are linked to a range of long-term adverse health effects, and it is thought that as well as aggravating symptoms, air pollution may contribute to the development of disease. DREaM will identify the ways in which the components in the air pollution mix affect people’s vulnerability to cardiovascular disease and the causal mechanisms behind this, by examining DNA modifications in key genes associated with air pollution. The findings will help to develop targeted mitigation actions and communication strategies to help people understand the risks to health.